Acta Paediatrica, EarlyView. Read on publisher site Sanna Hellström Schmidt, Ida Jeremiasen, Erik A. Eklund, Cornelis Jan Pronk Aim An electrocardiogram is commonly recommended in breath-holding spell management, mainly to rule out long QT syndrome. This retrospective study investigated the risk of long QT syndrome being misdiagnosed as breath-holding spells in a paediatric population in southern Sweden. Methods […]

Acta Paediatrica, EarlyView. Read on publisher site Michelle Ip, Sze Lut Cheng, Okkes R. Patoglu, Georgina Plunkett, Lauren C. Nisbet, Gillian M. Nixon, Margot J. Davey, Rosemary S. C. Horne Aim Children with Prader-Willi syndrome (PWS) are at increased risk of both central (CSA) and obstructive sleep apnoea (OSA). Studies examining the effects of growth hormone have focused on older children; however, […]

İskender Samet Daltaban1†, Mehmet Dumlu Aydın2, Eylem Eren Eyüpoğlu3, Elif Demirci4†, Aybike Aydin Okuyan5†Mehmet Emin Demir6*† Background: Excessive noise exposure is a known environmental health hazard linked to neurological injury and cognitive deficits. Whether complex sound waveforms from multiple sources exacerbate brain damage compared to a single-source noise of equal intensity remains unclear. We investigated […]

Focal cortical dysplasia (FCD) is a malformation of cortical development strongly associated with drug-resistant epilepsy, particularly in children but also observed in adults. FCD type II is specifically characterised by cortical disorganisation and the presence of abnormal cells. This condition has been widely linked to hyperactivation of the mTOR signalling pathway, secondary to somatic mutations. […]

by Nicole M. Chapman, Hongbo Chi Metabolic rewiring of immune cells has broad impacts on immune responses and disease outcomes. Systems biology approaches, such as multi-omics profiling and perturbation screening, could uncover new actionable targets and therapeutic avenues to explore. Metabolic regulation of immune function is a complex and dynamic process. This Perspective highlights how systems biology […]

Acta Paediatrica, Volume 115, Issue 2, Page 309-318, February 2026. Read on publisher site Lisanne M. van Leeuwen, Gina J. van Beveren, Marieke A. G. Peeters, Dennis Souverein, Sjoerd Euser, Debby Bogaert, Marlies A. van Houten Aim We examined the relationship between early-life antibiotics, different regimens, and growth until age five years. Methods Data from two parallel birth cohorts were analysed: […]

Acta Paediatrica, Volume 115, Issue 2, Page 408-417, February 2026. Read on publisher site Mattias Wennergren, Anna Fäldt, Anna Grimby-Ekman, Rajna Knez, Sofia Dalemo Aims To examine the association between the widely used social deprivation index, the Child Adjusted Care Need Index, and healthcare centres with a higher proportion of children with specific health risk factors monitored within the […]

Acta Paediatrica, Volume 115, Issue 2, Page 482-490, February 2026. Read on publisher site Sebiha Demir, Anne Groteklaes, Till Dresbach, Andreas Müller, Hemmen Sabir,  on behalf of the German Hypothermia Registry Aim There is a wide treatment heterogeneity for asphyxiated newborn infants between hospitals in Germany. This study aimed to identify the leading entry criteria initiating therapeutic hypothermia (TH) using data […]

Acta Paediatrica, Volume 115, Issue 2, Page 388-392, February 2026. Read on publisher site Jens C. R. Petersen, Laura E. Navne, Mette N. Svensen, Gorm Greisen Aim Perinatal loss is rare in high-income countries. In Danish neonatology, the psychosocial approach to neonatal care has been to acknowledge the personhood of the newborn infant with the goal of enabling […]

by Eric Alonso Abarca-Castro, José Javier Reyes-Lagos, Kioko Guzmán Ramos, Augusto J. Montiel-Castro, Hypatia Arano-Varela, Pablo Adolfo Mayer-Villa, José Eleazar Aguilar-Toalá, José Luis Montesillo-Cedillo and Ana Karen Talavera-Peña We offer an integrative perspective on how the air-pollution exposome shapes fetal development during the first 1,000 days and reverberates across mental health and behavior. Pregnant individuals […]

by Igor Belenichev, Olena Aliyeva, Nina Bukhtiyarova, Victor Ryzhenko, Bogdan Burlaka, Kristina Burlaka, Dmytro Skoryna, Pavlo Petakh, Oleksandr Kamyshnyi Prenatal hypoxia (PH) significantly impacts the central nervous system (CNS) development, often resulting in long-term cognitive, behavioral, and neurological deficits due to oxidative stress, mitochondrial dysfunction, and neuroapoptosis. The brain’s endogenous protective mechanisms are often insufficient […]

by David W Wolfson, Joshua A Hull, Yongwu Li, Trevor J Gonzalez, Mourya D Jayaram, Garth W Devlin, Valentina Cigliola, Kelsey A Oonk, Alan Rosales, Nenad Bursac, Aravind Asokan, Kenneth D Poss Tissue regeneration enhancer elements (TREEs) direct expression of target genes in injured and regenerating tissues. Additionally, TREEs of zebrafish origin were shown to […]

by Estefania Sanchez-Vasquez, Marianne E Bronner, Magdalena Zernicka-Goetz Human fertility is suboptimal in part by error-prone divisions during early cleavage stages, which frequently result in chromosomal aneuploidy. Most human pre-implantation embryos are mosaics of euploid and aneuploid cells, yet those with a low proportion of aneuploid cells can develop to term at rates similar to […]

by Giulio Gabrieli, Richard Somervail, André Mouraux, Massimo Leandri, Patrick Haggard, Gian Domenico Iannetti The spinal cord is the key bridge between the brain and the body. However, scientific understanding of healthy spinal cord function has historically been limited because noninvasive measures of its neural activity have proven exceptionally challenging. In this work, we describe […]