Karakaya et al. demonstrate that sustained dietary EPA exposure unmasks a latent metabolic vulnerability in the brain after TBI, driving maladaptive neurovascular remodeling, tauopathy, and cognitive decline. These findings challenge the paradigm of universal omega-3 neuroprotection and highlight the importance of metabolic context in brain injury outcomes.
Eicosapentaenoic acid reprograms cerebrovascular metabolism and impairs repair after brain injury, with relevance to chronic traumatic encephalopathy
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